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The renal clearance (.1 L/min) is unaffected by the route of dihydroergotamine administration. In addition, dihydroergotamine possesses oxytocic properties. Dihydroergotamine possesses oxytocic qualities and thus, should not be administered during pregnancy. When dihydroergotamine mesylate nasal spray was administered intranasally to woman rats during pregnancy and lactation, decreased body weights and impaired reproductive perform (decreased mating indices) had been observed in the offspring at doses of .16 mg/day or increased. A no influence degree was noticed at 1.2 mg/day (maternal exposures around 2.5 periods human exposures at the MRDD). Delayed skeletal ossification was also noted in rabbit fetuses adhering to intranasal administration of 3.6 mg/day (maternal exposures around seven periods human exposures at the MRDD) during organogenesis. Following nasal administration, overall metabolites represent only 20%-30% of plasma AUC. Quantitative pharmacokinetic characterization of the four metabolites has not been carried out. No pharmacokinetic interactions involving other cytochrome P450 isoenzymes are identified. Dihydroergotamine has also been proven to be an inhibitor of cytochrome P450 3A catalyzed reactions. P450 3A fat burning capacity of dihydroergotamine by troleandomycin. The decrease of plasma dihydroergotamine right after intramuscular or intravenous administration is multi-exponential with a terminal 50 %-existence of about nine several hours. Treatment consists of discontinuance of the drug, area application of warmth to the afflicted place, the administration of vasodilators and nursing treatment to stop tissue damage

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