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Below the line, each individual individual sequence duplication is indicated (with a unique colour) relative to for each cent nucleotide id for the duplicated segment (y axis). Until now, the identification and characterization of segmental duplications have been dependent on anecdotal reviews-for illustration, obtaining that particular probes hybridize to multiple chromosomal web sites or noticing duplicated sequence at selected recurrent chromosomal breakpoints. Several papers have analysed completed segments inside pericentromeric locations of chromosomes 2 (160 kb), 10 (400 kb) and 16 (300 kb), all of which clearly show considerable interchromosomal segmental duplication215,219,232,233. An lively pericentromeric region on chromosome 21. b, An ancestral location from Xq28 that has contributed many ‘genic’ segments to pericentromeric locations. Also, the subtelomeric end consists of a 50-kb region consisting just about entirely of interchromosomal duplications. The clarification for the clustering of segmental duplications may perhaps be that the genome has a injury-handle system whereby chromosomal breakage products are preferentially inserted into pericentromeric and, to a lesser extent, subtelomeric locations